TSLP, Thymic Stromal Lymphopoietin, human

TSLP, Thymic Stromal Lymphopoietin, human

Thương hiệu: Bio Basic-Canada | Tình trạng: Còn hàng

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TSLP, Thymic Stromal Lymphopoietin, human
CAT: RC213-18
Purity: >98% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C

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2ug

10ug

1mg

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TSLP, Thymic Stromal Lymphopoietin, human
CAT: RC213-18
Purity: >98% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.

Product Description: TSLP, Thymic Stromal Lymphopoietin, human: TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation., UnitProt ID: Q969D9

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