MIP-4, PARC, CCL18, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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MIP-4, PARC, CCL18, human
CAT: RC315-29
Purity: >97% by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C

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MIP-4, PARC, CCL18, human
CAT: RC315-29
Purity: >97% by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 100mM NaCl.

Product Description:MIP-4, PARC, CCL18, human: CCL18, is a novel CC chemokine that is highly homologous to MIP-1α (61% amino acid sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10 and IL-13, and inhibited by IFN-γ. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells, but not monocytes or neutrophils., UnitProt ID: P55774

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