IL-33, Interleukin-33, rat

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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IL-33, Interleukin-33, rat
CAT: RC252-44
Purity: > 95 % by SDS-PAGE and HPLC analyses
Storage:(-15 to -20)C

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IL-33, Interleukin-33, rat
CAT: RC252-44
Purity: > 95 % by SDS-PAGE and HPLC analyses
Storage:(-15 to -20)C
Sterile:Yes
Formulation: Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, pH 8.5

Product Description:IL-33, Interleukin-33, rat: Interleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a cytokine belonging to the IL-1 superfamily. It is also a proinflammatory protein that may regulate gene transcription and it induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33. IL-33 is constitutively expressed in smooth muscle and airway epithelia and it binds to a high-affinity receptor family member ST2. In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues. Recombinant rat IL-3 contains 156 amino acid residues and it shares 59 % a.a. and 90 % sequence identity with human and murine IL-33., UnitProt ID: Q66H70

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