IL-21, Interleukin-21, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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IL-21, Interleukin-21, human
CAT: RC212-32
Purity: >97% by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C

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IL-21, Interleukin-21, human
CAT: RC212-32
Purity: >97% by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C
Sterile: Yes
Stock: Inquire

Product Description: IL-21, Interleukin-21, human: IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3., UnitProt ID: Q9HBE4

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