IL-1RA, Interleukin-1 receptor antagonist, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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IL-1RA, Interleukin-1 receptor antagonist, human
CAT: RC212-12C
Purity: >95% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C

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IL-1RA, Interleukin-1 receptor antagonist, human
CAT: RC212-12C
Purity: >95% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.4

Product Description: IL-1RA, Interleukin-1 receptor antagonist, human: Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra.The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF., UnitProt ID: P18510

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