IL-15, Interleukin-15, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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IL-15, Interleukin-15, human
CAT: RC212-26
Purity: >96% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C

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IL-15, Interleukin-15, human
CAT: RC212-26
Purity: >96% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4

Product Description: IL-15, Interleukin-15, human: Interleukin 15 is a recently identified novel cytokine that shares many biological properties with IL-2, including T, B and NK cell-stimulatory activities. cDNA clones encoding this cytokine have been isolated from simian, murine and human cell sources. Human IL-15 shares approximately 97% and 73% sequence identity with simian and murine IL-15, respectively. Both human and simian IL-15 are active on murine cells. Human IL-15 cDNA encodes a 162 amino acid residue precursor protein containing a 48 amino acid residue signal peptide that is cleaved to yield the 114 amino acid residue mature protein. The IL-15 mRNA is expressed by a wide variety of cells and tissues and is most abundantly expressed by adherent peripheral blood mononuclear cells, fibroblasts and epithelial cells. However, in activated peripheral blood T lymphocytes where IL-2 is highly expressed, the expression of IL-15 is not detectable. Although IL-15 lacks sequence homology with IL-2, it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling. In addition, an IL-15 specific binding protein has also been cloned from a mouse T cell clone. (Grabstein, K. et al., 1994, Science 264:965; Giri, J. et al., 1994, EMBO J. 13:2822)., UnitProt ID: P40933

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