IL-13, Interleukin-13, rat

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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IL-13, Interleukin-13, rat
CAT: RC252-24
DG: No
Storage: (-15 to -20)C

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IL-13, Interleukin-13, rat
CAT: RC252-24
DG: No
Storage: (-15 to -20)C
Sterile: Yes
Stock: Inquire

Product Description: IL-13, Interleukin-13, rat: Interleukin-13 (IL-13) is expressed by the IL13 gene and secreted by many cell types, especially T helper type 2 (Th2) cells. The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Mature rat IL-13 shares 59 %, 75 %, and 60 % amino acid sequence identity with human, mouse, and rhesus IL-13, respectively., UnitProt ID: P42203

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