BD-3, beta-Defensin 3, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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BD-3, beta-Defensin 3, human
CAT: RC220-14
Purity: >98% by SDS-PAGE and HPLC analyses. to -20)C
Sterile: Yes

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BD-3, beta-Defensin 3, human
CAT: RC220-14
Purity: >98% by SDS-PAGE and HPLC analyses. to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 130mM NaCl.

Product Description: BD-3, beta-Defensin 3, human: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues., UnitProt ID: P81534

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